Wellapalooza 2016 – Dr. Afrin’s Presentation on Mast Cell Activation Syndrome (MCAS)

Dr. Lawrence Afrin's presentation at Wellapalooza 2016 focuses on Mast Cell Activation Syndrome (MCAS), a newly recognized form of mast cell disease characterized primarily by inappropriate activation of mast cells rather than overproduction, as seen in mastocytosis. Dr. Afrin explains the historical context and the divergence of MCAS from traditional allergic diseases and mastocytosis, elaborating on the complex interplay of genetic and environmental factors. Key genetic mutations, particularly in the KIT gene, play a significant role in the disorder's development and variability among patients. The presentation also highlights the evolution of understanding MCAS from initial hypotheses to identifying diverse genetic mutations affecting mast cell behavior, signaling the need for further research into diagnostic criteria and management strategies.