The Role of MCAS in Long Covid | With World Leading Specialist Dr Lawrence Afrin

In this comprehensive interview, Dr. Lawrence Afrin explores the connection between Mast Cell Activation Syndrome (MCAS) and Long Covid. Dr. Afrin discusses how mast cells play crucial roles in the immune system but can cause problems when they become dysregulated, leading to a wide variety of symptoms due to chronic multisystem inflammation. He notes that the symptoms can vary significantly between individuals, contributing to the medical community's lack of recognition of MCAS. Dr. Afrin explains that while the science behind MCAS is still developing, antihistamines are often the starting point for treatment given their efficacy in many cases. He also outlines the challenges in diagnosing MCAS, particularly due to the short lifespan of mast cell mediators and the lack of specific tests. Dr. Afrin advises MCAS patients to identify and avoid triggers, find an optimal antihistamine regimen, and progressively trial other possible treatments. Although antihistamines can significantly improve symptoms in some patients, MCAS remains a complex condition requiring more understanding and research.