The interplay between Mast Cell Activation Syndrome MCAS and breast implants

Dr. Tania Dempsey discusses the connection between Mast Cell Activation Syndrome (MCAS) and breast implant illness (BII). She explains that while everyone has mast cells, individuals with MCAS have dysfunctional mast cells that react excessively to various stimuli, resulting in chronic inflammation. In the context of breast implants, this dysfunction can be exacerbated by the implants themselves or remnants of silicone that may remain after removal. Dr. Dempsey notes that some patients continue to experience symptoms even after explant surgery, likely due to persistent mast cell activation. This can be attributed to leftover silicone, ongoing inflammation, or pre-existing mast cell abnormalities. The talk highlights the importance of considering MCAS in patients with persistent symptoms post-explant and suggests thorough strategies to manage these conditions.