Symptoms Of Mast Cell Activation

Dr. Theoharis Theoharides and host Haylie Pomroy outline common signs of mast cell activation, including itchy eyes and nose, facial flushing, gastrointestinal symptoms (bloating, abdominal pain), and episodes of breathing difficulty. They note that chronic stress can exacerbate mast cell activity and symptom flares. The discussion emphasizes careful evaluation and testing to distinguish MCAS from other conditions with overlapping symptoms, which guides selection of appropriate medications (e.g., antihistamines or other mast-cell–targeted therapies) and individualized management. Accurate diagnosis helps tailor treatment and improves outcomes.