Stress Is A Mast Cell Trigger

Dr. Theoharis C. Theoharides discusses the role of stress as a trigger for Mast Cell Activation Syndrome (MCAS). Research suggests that various forms of stress, such as psychological, physiological, economic, and political stresses, can activate mast cells, potentially leading to MCAS symptoms without the presence of an allergy. Dr. Theoharides emphasizes that the impact of stress on mast cells is well-documented, with specific biological pathways identified that link stress to mast cell activation. This understanding may help guide management strategies beyond traditional psychiatric approaches, offering more tailored interventions for MCAS patients.