Restless legs syndrome is associated with mast cell activation syndrome.

This study explores the link between Mast Cell Activation Syndrome (MCAS) and Restless Legs Syndrome (RLS), highlighting a significantly higher prevalence of RLS among those with MCAS compared to controls. In the study, 40.8% of MCAS patients experienced RLS, much higher than the spouse control group's 12.9%. The research suggests that inflammatory processes, immune responses, and dysautonomia or hypoxia associated with MCAS may trigger RLS. Differences in prevalence among genders in both patients and control groups were noted, with significant statistical findings primarily in male comparisons. This association underscores an important comorbidity consideration for clinicians treating MCAS patients.