Recognizing and Addressing Comorbidities in Complex Headache Disorders

In a recent review by Dr. Svetlana Blitshteyn, common comorbidities in complex headache disorders, particularly migraines, are highlighted. She notes that postural orthostatic tachycardia syndrome (POTS), hypermobility spectrum disorders (HSD), and mast cell activation syndrome (MCAS) often coincide with migraines, contributing to a challenging patient population. These disorders require comprehensive diagnostic and treatment approaches that are frequently overlooked in standard headache management. Dr. Blitshteyn emphasizes the importance of recognizing these overlaps, as treatments specific to dysautonomia, hypermobility, and mast cell disorders, such as dietary modifications and antihistamines, can significantly improve patient outcomes. She calls for more research and collaborative guidelines to better address these interconnected conditions.