Pregnancy in postural tachycardia syndrome: clinical course and maternal and fetal outcomes.

The study investigates the clinical course and maternal and fetal outcomes in pregnant women with pre-existing Postural Tachycardia Syndrome (POTS). It involved 10 women with POTS, resulting in 17 live births. Common pregnancy-related issues included a 59% incidence of severe vomiting or hyperemesis gravidarum in the first trimester, and two cases of pre-eclampsia. Despite these challenges, no stillbirths or congenital abnormalities were reported, and the majority of births were normal vaginal deliveries. POTS symptoms varied during and after pregnancy; 60% of women experienced improved or stable symptoms during pregnancy, while half showed improvement or stability six months postpartum. The study concludes that POTS may have a variable clinical progression during pregnancy, highlighting a potentially higher risk of severe vomiting in this population compared to the general population.