POTS: The Quest to Find An Underlying Cause - Dr. Blair Grubb

Dr. Blair Grubb's lecture from the 2015 Dysautonomia International Conference explores the diverse underlying causes and contributors to POTS or POTS-like syndromes. Dr. Grubb emphasizes that POTS is a clinical state rather than a specific disease, similar to congestive heart failure. He discusses how conditions like mitochondrial diseases, traumatic brain injuries, and multiple sclerosis can lead to POTS, highlighting the necessity for careful differential diagnosis. Research collaboration with the Cleveland Clinic unveiled mitochondrial dysfunction as a notable contributor, supporting the need for potential targeted therapies such as enzyme replacement. Dr. Grubb also discusses cases where POTS symptoms preceded the diagnosis of underlying neurological conditions like MS, suggesting that POTS may sometimes be an early sign of other complex diseases.