POTS Research Update and Q&A with Dr. Alexis Cutchins

Dr. Alexis Cutchins discussed various vascular compression syndromes associated with POTS, such as iliac vein compression and nutcracker syndrome, highlighting their role in exacerbating orthostatic intolerance and other POTS symptoms. She explained how blood pooling occurs due to venous insufficiency and the impact of connective tissue disorders like Ehlers-Danlos Syndrome. Dr. Cutchins emphasized the heterogeneity of POTS in terms of symptom presence and treatment response, noting the frequent coexistence of MCAS, which can complicate management due to its broad symptom profile and sensitivity issues. She touched on available treatments, including antihistamines and mast cell stabilizers, and discussed the emerging research on managing venous issues to potentially alleviate orthostatic symptoms in POTS patients. Her approach includes screening for vascular issues in POTS patients, given the high prevalence of comorbid conditions related to venous insufficiencies, though she cautioned that more research is necessary to establish definitive treatment protocols for these aspects.