POTS Research both Past and Future with Dr. Satish Raj

In this episode of the Standing Up to POTS podcast, Dr. Satish Raj, a prominent researcher in the field, discusses the history and future of POTS research, focusing on three main areas: blood volume abnormalities, autoimmunity, and issues with the norepinephrine transporter. Dr. Raj highlights the heterogeneity of POTS and the challenges it presents in research and treatment, noting that there is no single cause or treatment due to its varied nature. He discusses his research on the renin-aldosterone paradox in POTS patients, where aldosterone levels are unexpectedly low despite low blood volume, suggesting issues in salt handling regulation. The discussion also covers the potential role of autoimmunity in POTS, with interest sparked by findings of autoantibodies in some patients. Furthermore, Dr. Raj points out the importance of understanding norepinephrine transporter function, as issues here could contribute to POTS symptoms. Finally, Dr. Raj emphasizes the need for more structured studies and suggests that while searching for overarching solutions is important, incremental advances in management and treatment should also be pursued to effectively help patients. He underscores the complex interrelations between POTS, Ehlers-Danlos Syndrome, and Mast Cell Activation Syndrome.