Postural Orthostatic Tachycardia Syndrome Is Associated With Elevated G-Protein Coupled Receptor Autoantibodies.

This study investigates the potential autoimmune nature of Postural Orthostatic Tachycardia Syndrome (POTS) by examining the presence of autoantibodies against G-protein coupled adrenergic and muscarinic acetylcholine receptors in patients. The research involved 55 POTS patients and revealed significantly elevated autoantibodies, particularly against the adrenergic alpha 1 receptor in 89% of participants. These findings support the hypothesis that POTS may have an autoimmune component, contributing to its often misdiagnosed nature as anxiety or panic disorders. Additionally, the study highlights the commonality of comorbid conditions and viral-like symptoms preceding syncope episodes in primarily young female patients.