Platelet Storage Pool Deficiency and Elevated Inflammatory Biomarkers Are Prevalent in Postural Orthostatic Tachycardia Syndrome.

This study investigates the immune system's role in Postural Orthostatic Tachycardia Syndrome (POTS) by examining platelet storage pool deficiency and inflammatory biomarkers. The research demonstrates that many POTS patients have a platelet delta granule storage pool deficiency (δ-SPD) and elevated inflammatory cytokines and chemokines, particularly IL-1β and IL-18, suggesting an autoinflammatory component of POTS. These findings support the hypothesis that POTS may have an autoimmune basis, resembling a mixed-pattern inflammatory disease like rheumatoid arthritis. The study emphasizes the potential role of the innate immune system and T-cell-mediated processes in the etiology of POTS.