Perioperative Care in Patients with Ehlers Danlos Syndromes

This review highlights the unique anesthetic considerations for patients with Ehlers-Danlos Syndromes (EDS) undergoing surgery. It focuses on perioperative management due to EDS-related challenges such as connective tissue fragility, joint instability, and comorbidity with conditions like dysautonomia (including POTS) and MCAS. Preoperative evaluations are crucial for identifying risks like vascular fragility, craniocervical instability, and temporomandibular dysfunction. Anesthetic strategies should minimize manipulation of joints and spine and employ careful fluid and pain management to address issues like gastroparesis and opioid sensitivity. The paper emphasizes the need for customized perioperative care frameworks considering EDS's complex symptomatology and overlapping subtypes to optimize surgical outcomes.