Neuropsychiatric Manifestations of Mast Cell Activation Disease (MCAS) - Dr. Anne Maitland - ASAP

Dr. Anne Maitland discusses the complex interactions between mast cells and the nervous and immune systems, emphasizing their role in neuropsychiatric symptoms associated with Mast Cell Activation Syndrome (MCAS). Dr. Maitland outlines the historical neglect of mast cells in immunology and highlights their critical role in hypersensitivity reactions, chronic inflammation, and various conditions like EDS and POTS. She stresses the importance of considering MCAS in patients with multisystem symptoms and the potential for mast cells to misbehave due to genetic and environmental factors. The discussion covers diagnostic criteria for MCAS, the significant variability in individual responses due to mast cell behaviors, and the importance of a tailored treatment plan, which may include antihistamines, leukotriene inhibitors, and alternative therapies like acupuncture and lifestyle adjustments. Her insights also underline the need for personalized approaches in managing symptoms and improving the quality of life in affected patients.