Neuroimmunogastroenterology: Physiology and Diagnostics

Dr. Laura Pace discusses the complexities of diagnosing neurological disorders in gastroenterology, with a focus on the interplay between the nervous and immune systems within the gastrointestinal tract. She critiques the traditional approach of labeling unexplained symptoms as 'functional disorders' without sufficient diagnostic workup. Dr. Pace emphasizes the need for thorough evaluations, including innovative motility tests and consideration of immune-mediated components like mast cell infiltration. She highlights case studies illustrating how autonomic and neuroimmune dysfunctions can manifest with gastrointestinal symptoms, advocating for a nuanced approach to testing and diagnosis. This includes potentially using full-thickness biopsies and advanced imaging modalities to better understand underlying pathologies. Her research suggests some motility disorders might be treatable immune conditions, an insight that could reshape therapeutic strategies.