NET Dysfunction in POTS: 2017 Conference Research Study

The presentation by Dr. Satish Raj at the 2017 Dysautonomia International Conference focused on the dysfunction of the norepinephrine transporter (NET) and its implications for POTS. The presentation detailed a study conducted to investigate how NET dysfunction contributes to the hyperadrenergic state seen in POTS patients. It highlighted two mechanisms by which norepinephrine levels can increase: excessive release and impaired clearance due to NET dysfunction. The study explored the feasibility of measuring NET activity through RNA from blood samples, offering a practical approach to understand its role in POTS. The research aims to personalize treatment by understanding the individual variability in NET function among patients, noting that existing treatments like atomoxetine can worsen symptoms in some POTS patients due to their effect on norepinephrine clearance. This understanding could pave the way for more personalized medical interventions for POTS. The study emphasizes the underlying genetic and epigenetic influences that may affect NET function, although only two patients were found with the specific mutation causing NET dysfunction.