MCAS: Dr. Dempsey & Dr. Afrin

In this episode of the 'Thriving with Stripes' podcast, Dr. Tania Dempsey and Dr. Lawrence Afrin, both experts in Mast Cell Activation Syndrome (MCAS), provide insights into the condition. They discuss the role of mast cells, which are integral components of the immune system, and what occurs when their signaling becomes abnormal. The conversation covers the complexities of accurately diagnosing MCAS, including the challenges of testing for mast cell mediators due to their instability and the limitations of current laboratory capabilities. They emphasize that while MCAS is potentially prevalent, diagnosis should be based on definitive testing rather than symptom response to treatments. Treatment prioritizes identifying and avoiding triggers, tailoring antihistamine regimens, and methodically trialing other medications, with a focus on patient education and the exchange of information to support diagnosis and treatment. The episode also underscores the importance of a multi-faceted approach, incorporating lifestyle changes and possibly innovative therapies like neural retraining, while highlighting the necessity of patient and clinician persistence and patience in managing this complex condition.