Mastocytosis with Theoharis C. Theoharides, MS, PhD, MD, FAAAAI

This video features Theoharis C. Theoharides and discusses mastocytosis and broader mast cell activation disorders. It highlights that mastocytosis is characterized by an abnormal accumulation of mast cells, which are immune system cells that release chemicals causing allergy-like symptoms. Symptoms can include flushing, abdominal cramping, and anaphylaxis, among others. Diagnosis is based on clinical criteria and tests such as tryptase levels, though a definitive diagnosis might require a bone marrow biopsy. The video emphasizes the challenges in diagnosing mast cell disorders due to overlapping symptoms with other conditions. Management typically involves the use of medications like antihistamines and drugs that stabilize mast cells or block their mediators. The importance of recognizing and treating mast cell disorders early is emphasized, as well as the unpredictability of symptoms that can affect the quality of life.