Mast cells in the autonomic nervous system and potential role in disorders with dysautonomia and neuroinflammation.

This resource explores the critical role of mast cells (MC) in the context of the autonomic nervous system (ANS) and how they may contribute to the pathophysiology of dysautonomias, including postural orthostatic tachycardia syndrome (POTS) and mast cell activation syndrome (MCAS), as well as other neuroinflammatory disorders. The paper highlights that MCs, which are highly interactive with the ANS, are implicated in conditions with dysfunctional homeostatic mechanisms. MCs release various mediators affecting inflammation, vascular tone, and neuro-sensitization that could underlie symptoms in these conditions. The paper notes the lack of effective treatments, suggesting that future research should focus on inhibiting MC activation and mediator release, providing potential therapeutic targets for these complex disorders.