Mast Cell Dysfunction: It's Not Just Allergies by Anne Maitland, MD, PhD

In this presentation, Dr. Anne Maitland, an allergy and immunology expert, discusses the role of mast cells beyond traditional allergy responses, emphasizing their involvement in conditions like MCAS and Ehlers-Danlos Syndrome (EDS). She explores the relationship between immune system dysregulation, mast cell activation, and connective tissue disorders, noting that mast cells may contribute to symptoms in EDS and neurological disorders like Chiari malformation. Dr. Maitland outlines the role of mast cells in tissue repair and defense, highlighting their potential to influence pain, inflammation, and organ function. She also suggests that mast cell dysfunction could impact comorbidities like dysautonomia and provides criteria for diagnosing mast cell activation syndrome (MCAS). Various treatments, including avoidance strategies, medications targeting mast cells, and lifestyle changes, are discussed as part of management strategies for these conditions.