Mast Cell Disorders (Castells)

Dr. Mariana Castells discusses the management, symptoms, and diagnostic criteria of Mast Cell Activation Disorders in a conference presentation. She explains the classification of these disorders into primary, secondary, and idiopathic categories, highlighting the role of genetic factors like hereditary alpha tryptasemia. Dr. Castells emphasizes the importance of recognizing symptoms such as flushing, gastrointestinal issues, and anaphylaxis, along with the need for specific diagnostic biomarkers and genetic testing. She also reviews treatment strategies, which include both pharmacological options like tyrosine kinase inhibitors and biologics like omalizumab, and nonpharmacological approaches focusing on symptom and trigger management. The presentation stresses the need for personalized treatment plans and highlights ongoing research in the field.