Mast Cell Activation Syndrome with Dr. Leonard Weinstock: Rational Wellness Podcast 216

In this episode of the Rational Wellness Podcast, Dr. Leonard Weinstock, a board-certified gastroenterologist, discusses Mast Cell Activation Syndrome (MCAS) and its impact on gastrointestinal health with host Dr. Ben Weitz. Dr. Weinstock explains that MCAS is a chronic and often underdiagnosed condition characterized by inappropriate activation of mast cells, leading to widespread systemic symptoms including abdominal pain, bloating, diarrhea, and nausea. He emphasizes that MCAS is often misdiagnosed as functional gastrointestinal disorders like IBS and highlights the importance of comprehensive diagnostics, including blood and urine tests, to measure mast cell mediators such as histamine and tryptase. Effective treatments include antihistamines, dietary modifications, and mast cell stabilizers like quercetin. Dr. Weinstock also notes a potential overlap of MCAS with conditions such as POTS and discusses the role of stress management techniques as part of a holistic management strategy. The discussion underscores the need for increased awareness and tailored treatments to improve patient outcomes.