Mast Cell Activation Syndrome: What You Need to Know with Dr. Afrin

In this interview, Dr. Lawrence Afrin, a leading authority on mast cell activation syndrome (MCAS), discusses the intricacies of mast cells and their impact on chronic diseases. He explains how mast cells function as first responders in the immune system, releasing numerous chemicals known as mediators, which can lead to varied symptoms when released inappropriately. Dr. Afrin emphasizes that MCAS is a highly individualized condition, which can present through diverse symptoms including inflammation, allergic reactions, and abnormal growth patterns. He discusses common misconceptions and diagnostic challenges, emphasizing the need for personalized diagnosis and treatment. He also highlights the potential connection between MCAS and other conditions such as hypermobility and POTS, suggesting a possible shared underlying mechanism rooted in mast cell dysfunction.