Mast Cell Activation Syndrome : The Interplay Between Immunity and Neuroinflammation

Dr. Tania Dempsey presents on Mast Cell Activation Syndrome (MCAS) with a focus on its role in neuroinflammation and chemical intolerance. She explains that mast cells, part of the innate immune system, can become dysfunctional due to genetic and environmental factors, leading to a broad range of symptoms beyond allergies, including chronic inflammation and neuropsychiatric disorders. MCAS is categorized into primary, secondary, and idiopathic forms, with symptoms often affecting multiple organ systems. She highlights new insights into triggers like chemical intolerance and environmental toxins, and diagnostic challenges, including reliance on markers like tryptase. Dr. Dempsey advocates for individualized treatment plans, which could include medications like cromolyn, dietary changes, and targeted lifestyle adjustments, emphasizing the complexity and heterogeneity of MCAS and the need for a personalized approach to management.