Mast Cell Activation Syndrome: The Functional Medicine Approach

In this episode, Dr. Greg Plotnikoff discusses Mast Cell Activation Syndrome (MCAS) from a functional medicine perspective. He explains the role of mast cells as part of the immune system and what happens when they become hyperactive. The episode covers how MCAS can cause multi-system symptoms like flushing, brain fog, and chronic pain. Dr. Plotnikoff critiques conventional diagnostic methods, arguing that tryptase is not a reliable marker for MCAS, and suggests an empirical approach to treatment. He emphasizes the use of H1 and H2 blockers, dietary modifications such as low-histamine diets, and the importance of addressing psychosocial factors and stress. The episode highlights the significance of personalized treatment and the need for practitioners to support patients through complex diagnoses. Techniques like mind-body therapies are also considered important for managing MCAS.