Mast cell activation syndrome: Current understanding and research needs.

This review article on Mast Cell Activation Syndrome (MCAS) outlines the current understanding and knowledge gaps in this complex condition. Despite increased recognition, there is confusion over whether MCAS is a primary syndrome or a collection of symptoms related to other disorders. The article discusses the pathways of mast cell activation, which remain poorly understood, and identifies a need for more research in these areas. It covers the identification of MCAS and related conditions, diagnostic evaluations, and strategies for managing both typical and refractory symptoms. It also emphasizes the importance of education for both patients and healthcare providers about MCAS.