Mast Cell Activation Syndrome & Long COVID (E25) ft. Dr David Lyons Kaufman

In this podcast episode, Dr. David Lyons Kaufman discusses Mast Cell Activation Syndrome (MCAS) and its association with Long COVID. Dr. Kaufman describes MCAS as a condition leading to multi-system, chronic inflammation characterized by symptoms that often shift between different organ systems, making it hard to diagnose. The episode highlights the potential for MCAS to be triggered or exacerbated by infections such as COVID-19, suggesting that the syndrome could be more widespread than currently recognized. Dr. Kaufman explains the difference between MCAS and mastocytosis, noting that while the former is quite common, the latter is a rare, malignant condition. He emphasizes the importance of clinicians maintaining a high index of suspicion and recommends trialing anti-histamines as part of the diagnostic process. The conversation also touches on the challenges of accurate lab testing for MCAS and the frequent misdiagnosis of these patients. Dr. Kaufman advocates for broader awareness and understanding of MCAS within the medical community, aiming for improved diagnoses and management of the condition.