Mast Cell Activation Disease Current Concepts

In this resource, Dr. Afrin discusses Mast Cell Activation Syndrome (MCAS), a condition that is characterized by inappropriate activation of mast cells leading to the release of mediators that cause a wide array of symptoms. He highlights the extreme variability and heterogeneity in clinical presentations of MCAS, making it a challenge for clinicians to recognize and diagnose. Current diagnostic criteria are debated, and there are no FDA-approved treatments, with management heavily relying on expert opinion. He shares case studies to demonstrate different ways MCAS can manifest, such as blood disorders, burning mouth syndrome, and various forms of inflammation or allergic-like reactions. Despite the difficulty in diagnosis, he emphasizes the importance of recognizing and treating MCAS to improve patients' quality of life. Dr. Afrin encourages clinicians across specialties to learn about this disorder to better identify and manage it, as it can involve any organ system and has a high prevalence rate.