Mast cell activation: beyond histamine and tryptase.

This resource discusses the complexities of mast cell activation diseases (MCADs), with a focus on expanding the understanding of mast cell activation beyond just histamine and tryptase release. The authors highlight that mast cells can release a variety of mediators in response to diverse triggers, contributing to the broad range of symptoms seen in these conditions. Current pharmacological treatments target specific mediators or aim to prevent mast cell proliferation but do not sufficiently address mast cell activation itself. The complexity in diagnosing and treating MCADs is also underscored due to the involvement of mast cells in various disorders beyond primary mast cell activation syndrome (MCAS). The paper calls for refined diagnostic criteria and more comprehensive treatment approaches that consider the full spectrum of mast cell mediators.