Linking Mast Cell Activation, Autoimmunity, and EDS with Kara Wada, MD (Ep 103)

In this episode, Dr. Linda Bluestein interviews Dr. Kara Wada, an allergy immunology and lifestyle medicine expert, about the connections between the immune system, mast cell activation syndrome (MCAS), autoimmunity, and Ehlers-Danlos Syndrome (EDS). Dr. Wada explains differences between allergies and MCAS, emphasizing that MCAS can occur without traditional allergies. The podcast discusses chronic inflammation's role in autoimmune and connective tissue disorders, highlighting hormones' impact on immune function and autonomic conditions like POTS often seen in EDS. Dr. Wada outlines holistic management strategies, including anti-inflammatory diets and stress management practices. Pharmacological strategies, such as H1 and H2 blockers, Montelukast, and low-dose naltrexone, are discussed. The episode also covers the epithelial barrier hypothesis related to autoimmune conditions and the interconnectedness of bodily systems, advocating for personalized care strategies and effective communication between patients and healthcare providers.