Lessons from the US: Mast Cell Activation Syndrome #MCAS

In this episode of The Long COVID Clinic's Fireside Chats, Dr. Tania Dempsey, a renowned expert in Mast Cell Activation Syndrome (MCAS) and autoimmunity, discusses the complexities of diagnosing and treating MCAS. Dr. Dempsey highlights the challenges of diagnosing MCAS due to the lack of accessible and reliable tests, emphasizing the importance of clinical assessment and understanding patient history in identifying possible triggers. She explains that MCAS symptoms can overlap significantly with other conditions and stresses a personalized approach to treatment. Dr. Dempsey outlines a stepwise management approach, starting with environmental trigger identification and the use of antihistamines, with alternatives like ketotifen and cromolyn sodium for stabilizing mast cells. The discussion also touches on the interplay between MCAS and other conditions such as POTS, EDS, and chronic infections, and how these can exacerbate symptoms. Additionally, the role of diet and the implications of mold exposure are explored, along with the importance of addressing the autonomic nervous system to manage symptoms effectively. The episode offers insights into how functional and integrative medicine can significantly benefit those diagnosed or suspected of having MCAS.