Ivabradine in children with postural orthostatic tachycardia syndrome: a retrospective study.

This retrospective cohort study evaluates the use of ivabradine in treating children with postural orthostatic tachycardia syndrome (POTS). The study reviewed medical records of 27 children who were administered ivabradine, focusing on changes in symptoms, heart rate, and blood pressure before and after treatment. Results indicated that 67% of participants experienced symptom improvement, particularly in syncope/presyncope, lightheadedness, and fatigue. There was a significant reduction in heart rate during both sitting and standing positions, without notable changes in blood pressure. Some side effects included visual disturbances, bradycardia, flushing, joint pain, and fatigue, affecting a minority of participants.