Is postural orthostatic tachycardia syndrome (POTS) a central nervous system disorder?

The review article by Svetlana Blitshteyn argues that Postural Orthostatic Tachycardia Syndrome (POTS) is not only a disorder of the peripheral nervous system but also involves the central nervous system (CNS). This perspective is supported by evidence such as significant CNS symptoms in POTS patients, structural and functional neuroimaging findings, cerebral hypoperfusion, and response to CNS-targeted treatments. By redefining POTS as a CNS disorder, the paper suggests that this could open up new avenues for both pharmacological and non-pharmacological therapies, potentially improving management strategies for patients facing this syndrome.