Inflammatory Biomarkers in POTS Patients - Dr. Blair Grubb

In his lecture, Dr. Blair Grubb discusses the relationship between Postural Orthostatic Tachycardia Syndrome (POTS) and Mast Cell Activation Syndrome (MCAS), focusing on the role of the immune system and inflammatory biomarkers. He explains how many POTS patients exhibit elevated adrenergic and muscarinic autoantibodies, suggesting an autoimmune component to the condition. Grubb's research indicates that there is a significant presence of inflammatory cytokines and chemokines, suggesting both autoimmune and autoinflammatory mechanisms. Through case studies and examples, he emphasizes the complexity of autonomic disorders and the importance of recognizing overlapping conditions, which can lead to better management strategies and treatment options, such as immunotherapy in severe cases.