Hypermobile Ehlers-Danlos syndrome (a.k.a. Ehlers-Danlos syndrome Type III and Ehlers-Danlos syndrome hypermobility type): Clinical description and natural history.

This resource provides a comprehensive overview of hypermobile Ehlers-Danlos syndrome (hEDS), focusing on its clinical manifestation and natural history. hEDS is characterized primarily by musculoskeletal issues, such as joint hypermobility, subluxations, dislocations, and various skin and soft tissue symptoms. Many patients experience activity-related pain, and some suffer from chronic daily pain. The resource describes the complexity in diagnosing hEDS, as it is often clinically identified in absence of other explanations, and its overlap with joint hypermobility syndrome, which has led to the current nosological classification. The review offers a detailed description of symptoms and related disorders, aiding in improving clinical understanding and potentially guiding diagnostic processes.