Hyperadrenergic POTS by Dr David Saperstein - #shorts

Dr. David Saperstein explains that hyperadrenergic POTS is a subtype of POTS marked by excessive sympathetic activation. Diagnostic features include plasma norepinephrine levels over 600 pg/mL and a rise in systolic blood pressure of more than 10 mmHg after 10 minutes of standing (typically assessed during standing tests or tilt-table testing with catecholamine measurements). Patients often experience symptoms that can resemble anxiety—such as palpitations, tremulousness, and feeling on edge—but these are driven by physiologic adrenergic excess rather than a primary anxiety disorder, and symptoms can be functionally disabling. The clip emphasizes recognizing objective criteria to avoid misdiagnosis and to guide appropriate management.