Hemodynamic Effects of the Osmopressor Response: A Systematic Review and Meta-Analysis.

This systematic review and meta-analysis investigates the impact of rapid water consumption on hemodynamic parameters in individuals with orthostatic hypotension, multiple system atrophy, pure autonomic failure, and postural tachycardia syndrome (POTS). Results indicate that consuming 350-500 mL of water rapidly increases systolic and diastolic blood pressure (BP), while slightly reducing heart rate in patients with orthostatic hypotension in seated or supine positions. Healthy individuals experience milder effects. Notably, no significant changes were observed in POTS patients when seated or supine, but the study did not evaluate standing effects. The findings suggest potential benefits of rapid water intake for managing orthostatic hypotension, but further research is needed to explore its effects in POTS during standing.