Dysautonomia, Hypermobility Spectrum Disorders and Mast Cell Activation Syndrome as Migraine Comorbidities.

The resource explores the intersection of migraines with conditions like POTS, hypermobility spectrum disorders (HSD), and mast cell activation syndrome (MCAS), emphasizing their frequent co-occurrence. Migraine is notably common in individuals with these disorders, which can present challenges in diagnosis and treatment due to their overlapping symptoms and shared pathophysiological mechanisms. It highlights the importance of clinicians maintaining a high level of suspicion and being equipped with proper diagnostic criteria and treatment protocols to effectively manage patients who experience both migraines and these comorbid conditions. Addressing these comorbidities is crucial for reducing symptom burden and enhancing the overall quality of life for affected patients.