Dr. Theo Theoharides on mast cells driving dysautonomia and much more - Mast Cell Matters

In this podcast episode of Mast Cell Matters, Dr. Theo Theoharides discusses his prolific research on mast cells and their complex roles in various conditions including dysautonomia and Ehlers-Danlos Syndrome (EDS). He highlights the role of mast cells in neuroinflammation and their potential impact on conditions like autism, ME/CFS, and long COVID. Dr. Theoharides argues for considering mast cell activation disorders broadly rather than focusing strictly on Mast Cell Activation Syndrome (MCAS). He emphasizes the limitations of current diagnostic and treatment methods, pointing out the need for more research into pharmacological and non-pharmacological therapies, including the efficacy of certain flavonoids like Luteolin. The episode underscores the challenges in understanding and treating mast cell related disorders due to the variability in mast cell function and the lack of targeted funding for this research area.