Dr. T. C. Theoharides presents “Mast Cell Disorders”

Dr. Theoharis C. Theoharides presents on mast cell disorders, particularly focusing on Mast Cell Activation Syndrome (MCAS) and its surprising prevalence among patients with Ehlers-Danlos Syndrome (EDS) and Postural Orthostatic Tachycardia Syndrome (POTS). He discusses the symptoms of mast cell disorders such as headaches, pain, fatigue, disautonomia, and neurologic complaints. An important point raised is the high comorbidity between MCAS and EDS and the challenges in diagnosis, due in part to the lack of objective tests for some variations. The presentation underscores the complexity of these disorders, highlighting overlaps in symptoms and genetic predispositions, and integral roles of neurotransmitters and environmental triggers. Current management approaches include antihistamines and lifestyle adjustments, though Dr. Theoharides also mentions ongoing efforts to better understand non-allergenic triggers and develop effective treatments. He elaborates on the difficulty of diagnosing MCAS, emphasizing the importance of individualized patient management and the potential for certain drugs and natural compounds to alleviate symptoms.