Dr. Lawrence Afrin: MCAS 101 with EDS Twist January 2021

In this presentation, Dr. Lawrence Afrin provides an in-depth overview of Mast Cell Activation Syndrome (MCAS) and its connections with Ehlers-Danlos Syndrome (EDS). MCAS, a complex disorder characterized by inappropriate activation of mast cells, often presents with diverse and systemic symptoms that can go unrecognized for years. Dr. Afrin explains that the variability in symptoms is due to the different mutations that affect mast cell behavior, leading to a wide range of inflammatory responses. While discussing the diagnostic criteria and the challenges in testing, Dr. Afrin emphasizes the importance of a comprehensive history and symptom analysis in diagnosing MCAS. He also touches on potential connections between MCAS and EDS, hypothesizing that MCAS could play a role in the connective tissue abnormalities seen in some EDS patients, though more research is needed. In terms of treatment, Dr. Afrin suggests that both pharmacological and non-pharmacological approaches are used, acknowledging the lack of clinical trials in this area. Importantly, he highlights the need for rigorous further research to better understand the potential causative links and to develop effective treatments. The session includes a Q&A where Dr. Afrin addresses practical concerns and comorbidities related to these conditions.