Dr. Jeffrey Boris on MCAS, POTS, hypermobility and pediatric cardiology as part of the Mast Cell Matters Series with Dr. Tania Dempsey

In this podcast episode, pediatric cardiologist Dr. Jeffrey Boris discusses the intersection of Mast Cell Activation Syndrome (MCAS), Postural Orthostatic Tachycardia Syndrome (POTS), and hypermobility syndromes often referred to as 'the triad', which he encounters frequently in his practice. Dr. Boris highlights a study showing that 70% of his POTS patients also have MCAS, suggesting a higher prevalence than previously reported. He emphasizes a personalized approach to treatment, focusing on both pharmacological measures, like antihistamines and beta blockers, and nonpharmacological interventions, including exercise per a modified Dallas protocol. Dr. Boris reports the significance of identifying underlying comorbidities, such as Sjogren's Syndrome, and addresses the relevance of genetic markers in POTS. The conversation also touches on how hormonal factors and the potential for MCAS to influence cholesterol might interconnect these conditions. Dr. Tania Dempsey adds insights on the potential effects of MCAS on liver function and cholesterol levels and the varied presentations and comorbidities seen in adult versus pediatric populations. Both experts stress the importance of personalized and patient-driven management strategies.