Dr. David Kaufman on ME/CFS, MCAS, POTS and complex disorders - Mast Cell Matters Series

In this interview, Dr. David Kaufman and Dr. Tania Dempsey discuss the complexities of MCAS, ME/CFS, POTS, and related disorders, emphasizing the interconnectedness of these conditions, which they define as a 'septad'. They explore the idea that mast cell activation syndrome (MCAS) often accompanies other conditions like EDS and POTS, driven by genetic predispositions and environmental factors such as infections or toxins. Dr. Kaufman explains that these patients usually have multiple coexisting issues, and traditional silos in medical training may hinder effective diagnosis and treatment. They discuss the potential role of persistent infections and immune system dysfunction, noting that inflammation and environmental factors exacerbate these conditions. Dr. Kaufman highlights the use of rapamycin, an anti-aging compound, as a potential treatment for complex chronic illnesses due to its ability to enhance autophagy and immune function. They stress the importance of broad spectrum diagnostic testing and personalized treatment plans, advocating for a more integrated approach to managing these conditions.