Detection of G Protein-Coupled Receptor Autoantibodies in Postural Orthostatic Tachycardia Syndrome Using Standard Methodology.

This study investigates the presence of autoantibodies to cardiovascular G protein-coupled receptors in patients with Postural Orthostatic Tachycardia Syndrome (POTS) compared to healthy controls. Involving 116 POTS patients and 81 healthy controls, the research utilized enzyme-linked immunosorbent assays to test for autoantibodies against several receptors. Results showed no significant differences in autoantibody concentrations between the two groups, suggesting these tests do not support the role of autoimmunity in POTS. This implies that current assays of these autoantibodies may not be effective for diagnosing POTS or assessing its underlying immune mechanisms.

Testing Underlying Mechanisms Diagnosis / Diagnostic Criteria
Published June 30, 2022
Detection of G Protein-Coupled Receptor Autoantibodies in Postural Orthostatic Tachycardia Syndrome Using Standard Methodology.
Contributors
Source

Circulation

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