Clinical Practice Updates: AGA Clinical Practice Update on GI Manifestations and Autonomic or Immune Dysfunction in Hypermobile Ehlers-Danlos Syndrome: Expert Review.

This resource provides a comprehensive review of the gastrointestinal (GI) manifestations associated with hypermobile Ehlers-Danlos syndrome (hEDS) and hypermobility spectrum disorders (HSDs), particularly when coexisting with conditions like postural orthostatic tachycardia syndrome (POTS) and mast cell activation syndrome (MCAS). The authors discuss best practices in evaluating and managing these conditions, emphasizing awareness of their associations and the need for targeted testing rather than universal screening for POTS/MCAS in all hEDS/HSD patients. They recommend using the Beighton score for joint hypermobility screening and diagnostic criteria for hEDS. The review outlines when to consider MCAS testing and describes management strategies for GI symptoms through lifestyle adjustments, pharmacological treatments, and dietary modifications. It stresses the importance of integrated multidisciplinary care involving various specialties for optimal management of these complex conditions.