Cardiovascular symptoms in patients with systemic mast cell activation disease.

The article discusses the cardiovascular symptoms associated with mast cell activation disease (MCAD), focusing particularly on mast cell activation syndrome (MCAS). The authors explain that MCAS involves inappropriate mast cell activation without significant neoplastic activity, distinguishing it from mastocytosis. The condition is associated with a wide range of symptoms due to the release of various mast cell mediators. The paper delves into the pathogenesis of these symptoms, emphasizing the complex and multifaceted nature of MCAS, and highlights management strategies for cardiovascular symptoms caused by mast cell mediator release. This includes exploring pharmacological interventions to mitigate these effects.