Bupropion in the treatment of postural orthostatic tachycardia syndrome (POTS): a single-center experience.

This study examines the use of bupropion in treating patients with Postural Orthostatic Tachycardia Syndrome (POTS). Through a retrospective chart review of 47 POTS patients, the researchers evaluated the effectiveness of bupropion, a norepinephrine and dopamine reuptake inhibitor, in managing POTS symptoms, particularly focusing on orthostasis and syncope. The findings reveal that while bupropion does not significantly improve orthostatic vitals, it does reduce the frequency of syncope, indicating its potential utility for POTS patients with predominant syncope symptoms. This suggests that bupropion may be a beneficial treatment option for certain subsets of POTS patients, despite not impacting orthostatic vitals broadly.