Biomarkers - Are we Close? with Dr. Clair Francomano (Ep 118)

In this episode of the Bendy Bodies podcast, Dr. Clair Francomano discusses the current understanding and challenges in diagnosing hypermobile Ehlers-Danlos Syndrome (hEDS). She distinguishes between hEDS and hypermobility spectrum disorders (HSD), suggesting they may often overlap and warrant unified diagnostic criteria. Despite the absence of genetic markers for hEDS, emerging biomarkers like fibronectin show potential for aiding diagnosis in the future. Dr. Francomano addresses the complex interrelations between EDS, POTS, and MCAS, emphasizing a holistic management approach due to their frequent comorbidity. She underscores the importance of comprehensive diagnostic criteria and careful assessment of family history and personal health to rule out other hereditary disorders, highlighting current research efforts and potential advancements in understanding these conditions.