Anaphylaxis, Mast Cell Activation Syndrome, or Something Else?

Dr. Anne Maitland discusses anaphylaxis and Mast Cell Activation Syndrome (MCAS), highlighting diagnostic challenges and management strategies. Anaphylaxis, although historically rare, now affects a significant portion of the population and involves multi-organ system reactions often triggered by allergies or other immune responses. MCAS, a newer diagnosis, involves immediate hypersensitivity reactions without clear allergic triggers. Both conditions can be difficult to diagnose due to their resemblance to other disorders. Dr. Maitland emphasizes the need for thorough screening and symptom evaluation, especially in patients with related conditions like dysautonomia and hypermobility. She advocates for patient education on triggers, the importance of epinephrine as a first-line treatment for anaphylaxis, and interdisciplinary management approaches to improve patient outcomes.